Nielsen P, Friis C, Kraul I, Olsen C E
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
Res Vet Sci. 1993 Jan;54(1):72-9. doi: 10.1016/0034-5288(93)90014-7.
4-Methylimidazole (MeI) is formed when hay is ammoniated and it has been suspected of being the compound causing the 'crazy cow' syndrome. The aim of the present study was to describe the disposition of MeI in goats and heifers. The mean residence time was about five hours and the volume of distribution 0.9 litre kg-1 bodyweight in both goats and heifers. Goats metabolised MeI to a much higher extent than heifers which excreted the major part as the unchanged compound. MeI and its metabolites were excreted mainly in urine, but also in milk and faeces. In spite of administration of a dose (20 mg kg-1 bodyweight) which is much higher than the one intoxicated animals may have received through contaminated fodder none of the typical signs of intoxication were observed and it is concluded that MeI may not alone be the cause of the 'crazy cow' syndrome.
当干草进行氨化处理时会形成4-甲基咪唑（MeI），人们怀疑它是导致“疯牛”综合征的化合物。本研究的目的是描述MeI在山羊和小母牛体内的处置情况。平均驻留时间约为5小时，山羊和小母牛的分布容积均为0.9升/千克体重。山羊对MeI的代谢程度比小母牛高得多，小母牛主要以未变化的化合物形式排泄大部分MeI。MeI及其代谢产物主要通过尿液排泄，但也通过乳汁和粪便排泄。尽管给予的剂量（20毫克/千克体重）远高于中毒动物可能通过受污染饲料摄入的剂量，但未观察到任何典型的中毒迹象，因此得出结论，MeI可能不是“疯牛”综合征的唯一病因。
