Funkhouser E, Waterbor J W, Cole P, Rubin E
Department of Epidemiology, School of Public Health, University of Alabama, Birmingham 35294-0008.
South Med J. 1993 Feb;86(2):177-80. doi: 10.1097/00007611-199302000-00006.
We assessed the association between Wolfe mammographic patterns and breast cancer risk factors among 239 women who attended the Breast Evaluation Unit screening program of the Comprehensive Cancer Center of Alabama, University of Alabama at Birmingham, from November 1984 through April 1986. Evaluation consisted of a breast cancer risk assessment based on a questionnaire concerning commonly accepted breast cancer risk factors, along with a physical breast examination and mammogram. Increased age, weight, and parity were associated with a low-risk pattern; late age at first birth, alcohol consumption, and oral contraceptive use were associated with a high-risk pattern. Our findings support those of previous studies, except for those concerning use of oral contraceptives. Further exploration is needed to ascertain whether the association of oral contraceptive use with high-risk patterns indicates a pathway through which estrogens may increase the risk of breast cancer.
1984年11月至1986年4月期间，我们对阿拉巴马大学伯明翰分校综合癌症中心乳腺评估单元筛查项目中的239名女性进行了研究，评估了沃尔夫乳房X线摄影模式与乳腺癌风险因素之间的关联。评估内容包括基于一份关于公认乳腺癌风险因素的问卷进行的乳腺癌风险评估，以及乳房体格检查和乳房X线摄影。年龄增长、体重增加和多产与低风险模式相关；初产年龄晚、饮酒和使用口服避孕药与高风险模式相关。我们的研究结果支持了先前研究的结果，但关于口服避孕药的研究除外。需要进一步探究口服避孕药使用与高风险模式之间的关联是否表明雌激素可能增加乳腺癌风险的一种途径。
