精原细胞瘤中碱性磷酸酶同工酶的免疫病理学

Immunopathology of alkaline phosphatase isozymes in seminoma.

作者信息

Yamamoto H, Uchibayashi T, Koshida K, Hirano K, Hisazumi H

机构信息

Department of Urology, Kanazawa University, Japan.

出版信息

Urol Int. 1993;50(1):33-5. doi: 10.1159/000282444.

DOI:10.1159/000282444

PMID:8434423

Abstract

An immunohistopathological study using monoclonal antibodies for alkaline phosphatases demonstrated placental alkaline phosphatase (PLAP)-like substance in the tumor cells of 11 pure seminomas, 1 seminoma with embryonal carcinoma and 1 seminoma metastasis. Liver alkaline phosphatase (LAP) could also be demonstrated in all seminomas but a third intestinal alkaline phosphatase (IAP) was not demonstrable in any tumor. The PLAP-like substance and LAP had considerable enzyme activities. This provides two tumor markers of seminomas detectable in histopathological specimens.

摘要

一项使用碱性磷酸酶单克隆抗体的免疫组织病理学研究表明，在11例纯精原细胞瘤、1例伴有胚胎癌的精原细胞瘤和1例精原细胞瘤转移灶的肿瘤细胞中存在胎盘碱性磷酸酶（PLAP）样物质。在所有精原细胞瘤中也可检测到肝碱性磷酸酶（LAP），但在任何肿瘤中均未检测到第三种肠碱性磷酸酶（IAP）。PLAP样物质和LAP具有相当的酶活性。这提供了两种可在组织病理学标本中检测到的精原细胞瘤肿瘤标志物。