莫氏综合征A（黏多糖贮积症IVA型）基因定位于16q24.3。
The morquio A syndrome (mucopolysaccharidosis IVA) gene maps to 16q24.3.
作者信息
Baker E, Guo X H, Orsborn A M, Sutherland G R, Callen D F, Hopwood J J, Morris C P
机构信息
Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.
出版信息
Am J Hum Genet. 1993 Jan;52(1):96-8.
Abstract
The gene for N-acetylgalactosamine-6-sulfatase, the deficiency of which results in Morquio A syndrome (mucopolysaccharidosis type IVA), was assigned to chromosome 16 at band q24.3 by fluorescence in situ hybridization. Localization of this band was confirmed by PCR analysis of a somatic cell hybrid panel used for fine mapping of chromosome 16.
摘要
N-乙酰半乳糖胺-6-硫酸酯酶的基因，其缺乏会导致莫尔基奥A综合征（IVA型黏多糖贮积症），通过荧光原位杂交被定位到16号染色体q24.3带。通过对用于16号染色体精细定位的体细胞杂交板进行PCR分析，证实了该带的定位。
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