正常妊娠对尿酸肾脏处理的影响。

The effect of normal pregnancy upon the renal handling of uric acid.

作者信息

Dunlop W, Davison J M

出版信息

Br J Obstet Gynaecol. 1977 Jan;84(1):13-21. doi: 10.1111/j.1471-0528.1977.tb12459.x.

DOI:10.1111/j.1471-0528.1977.tb12459.x

Abstract

Twenty-four women were investigated serially during and after normal pregnancy. Plasma uric acid concentration appeared to be inversely related to uric acid clearance under infusion conditions, and comparison with simultaneous inulin clearance suggested an alteration in renal function resulting in increased 'net tubular reabsorption' of uric acid as pregnancy progressed. No difference was detected between primigravidae and multigravidae. The implications of these changes are discussed with reference to the renal handling of uric in pre-eclampsia.

摘要

对24名正常妊娠期间及产后的女性进行了连续研究。在输注条件下，血浆尿酸浓度似乎与尿酸清除率呈负相关，与同时测定的菊粉清除率比较表明，随着妊娠进展，肾功能发生改变，导致尿酸“肾小管净重吸收”增加。初产妇和经产妇之间未检测到差异。参照子痫前期中尿酸的肾脏处理情况，对这些变化的影响进行了讨论。