Martin B J, Lyon T D, Walker W, Fell G S
Department of Geriatric Medicine, Lightburn Hospital, Glasgow, UK.
Ann Clin Biochem. 1993 Jan;30 ( Pt 1):23-7. doi: 10.1177/000456329303000104.
Serum and mononuclear blood cell (MBC) magnesium were measured in 24 healthy community subjects, average age 76 years (67-93), and in 21 ill hospitalized subjects, average age 79 years (65-90). MBC magnesium, expressed as mumol/mg protein, was significantly lower in the in-patient group (P < 0.001), but tended to be higher in the same group when expressed as fmol/cell (not significant). Further samples from community subjects on the same day, and again at 7 days, revealed coefficients of variation for intrasubject analysis of 12% and 22%, respectively (fmol/cell). The equivalent intrasubject values for serum were 2.8% on the same day and 4% at 1 week. MBC magnesium values for inpatients were probably distorted by changes in cell size and cell protein content caused by illness. Biological variability and the effects of illness on the composition and size of cells seem to limit the usefulness of MBC magnesium measurement as a clinical tool for assessment of body magnesium status.
对24名健康社区受试者（平均年龄76岁，67 - 93岁）和21名住院患者（平均年龄79岁，65 - 90岁）的血清和单核血细胞（MBC）镁含量进行了测量。以μmol/mg蛋白表示的MBC镁含量，住院患者组显著更低（P < 0.001），但以fmol/细胞表示时，该组含量则有更高的趋势（无显著性差异）。同一天对社区受试者再次采样，并在7天后再次采样，结果显示，受试者内分析的变异系数分别为12%和22%（fmol/细胞）。血清的等效受试者内值在同一天为2.8%，在1周时为4%。住院患者的MBC镁含量值可能因疾病导致的细胞大小和细胞蛋白含量变化而失真。生物变异性以及疾病对细胞组成和大小的影响似乎限制了MBC镁含量测量作为评估机体镁状态的临床工具的实用性。
