Antonipillai I, Murphy B E
Br J Obstet Gynaecol. 1977 Mar;84(3):179-85. doi: 10.1111/j.1471-0528.1977.tb12552.x.
Whereas maternal venous levels of progesterone and oestrogens have been studied intensively in relation to parturition, little attention has been directed to fetal levels. In this study progesterone, oestrone (E1), oestriol (E2) and oestriol (E3) were measured in umbilical artery (UA) and umbilical vein (UV) serum at vaginal delivery (after induced or spontaneous onset of labour) and at elective Caesarean section. At least 14 samples were included in each group. All UV serum steroid levels were consistently higher than UA serum steroid levels. Cord serum levels of progesterone and arterio-venous differences were higher at vaginal delivery than at Caesarean section although maternal levels changed little. E1 and E2 levels were similar after spontaneous labour and at Caesarean section but were higher (P less than 0-05) after induced labour although E3 levels did not alter. E1 and E2 were higher and progesterone lower in primiparae than in multiparae. Fetal sex made no differences. These results suggest that induction of labour with oxytocin results in altered fetal hormone levels, that maternal hormone levels provide a poor reflection of fetal changes,and that current views about the mechanism of the onset of labour in animals may not be appropriate for man.
鉴于已对母体静脉中孕酮和雌激素水平与分娩的关系进行了深入研究，但对胎儿体内的这些激素水平却很少关注。在本研究中，对经阴道分娩（引产或自然发动分娩后）及择期剖宫产时脐动脉（UA）和脐静脉（UV）血清中的孕酮、雌酮（E1）、雌二醇（E2）和雌三醇（E3）进行了测定。每组至少纳入14份样本。所有UV血清类固醇水平始终高于UA血清类固醇水平。尽管母体激素水平变化不大，但经阴道分娩时脐带血清孕酮水平及动静脉差值高于剖宫产时。自然分娩后和剖宫产时E1和E2水平相似，但引产术后E1和E2水平更高（P＜0.05），而E3水平无变化。初产妇的E1和E2水平较高，孕酮水平较低，经产妇则相反。胎儿性别对结果无影响。这些结果表明，催产素引产会导致胎儿激素水平改变，母体激素水平不能很好地反映胎儿的变化，而且目前关于动物分娩发动机制的观点可能不适用于人类。
