Maynard P V, Stein P E, Symonds E M
Br J Obstet Gynaecol. 1980 Oct;87(10):864-8. doi: 10.1111/j.1471-0528.1980.tb04438.x.
The progesterone concentration in the umbilical venous and arterial plasma has been measured by radioimmunoassay. In 35 normal spontaneous vaginal deliveries the concentration in the umbilical venous plasma was highly correlated with the difference between venous and arterial plasma concentrations. There was no correlation of progesterone levels with infant birth weight or placental weight, but slightly higher amounts were found in samples taken from women with female fetuses than those with male fetuses. There was also a significant correlation of venous progesterone concentration with duration of labour. In 14 subjects where forceps were used to assist delivery because of prolonged second stage labour, progesterone levels were found to be elevated, whereas in nine cases of elective Caesarean section they were reduced. It is suggested that the fetus may stimulate progesterone secretion by the placenta in response to stress and that there may also be a fetal sex-related response.
已通过放射免疫分析法测定了脐静脉和动脉血浆中的孕酮浓度。在35例正常自然阴道分娩中，脐静脉血浆中的浓度与静脉和动脉血浆浓度之差高度相关。孕酮水平与婴儿出生体重或胎盘重量无相关性，但从女胎孕妇采集的样本中发现的孕酮量略高于男胎孕妇。静脉孕酮浓度与产程也存在显著相关性。在14例因第二产程延长而使用产钳辅助分娩的产妇中，发现孕酮水平升高，而在9例择期剖宫产病例中，孕酮水平降低。提示胎儿可能在应激反应下刺激胎盘分泌孕酮，并且可能还存在与胎儿性别相关的反应。
