Berrisford R G, Sabanathan S, Mearns A J, Clarke B J, Hamdi A
Department of Thoracic Surgery, Bradford Royal Infirmary.
Br J Anaesth. 1993 Feb;70(2):201-4. doi: 10.1093/bja/70.2.201.
Plasma concentrations of bupivacaine have been measured in 12 patients given bupivacaine through a paravertebral catheter placed under direct vision at thoracotomy. After an initial bolus of 0.5% bupivacaine 20 ml, mean (SEM) Cpmax was 1.45 (0.32) micrograms ml-1 and median (range) tCpmax was 25 (10-60) min. A concentration of 4.43 micrograms ml-1 measured in one patient was not associated with toxic signs. During continuous infusion of bupivacaine for 120 h, Cpmax was 4.9 (0.7) micrograms ml-1 and tCpmax 48 (5-96) h. No symptoms or signs of toxicity occurred. Separate measurement of R- and S-bupivacaine concentrations demonstrated significantly different concentration-time profiles.
对12例在开胸手术直视下经椎旁导管给予布比卡因的患者测定了血浆布比卡因浓度。在首次推注20 ml 0.5%布比卡因后，平均（标准误）Cpmax为1.45（0.32）μg/ml，中位数（范围）tCpmax为25（10 - 60）分钟。在1例患者中测得的4.43μg/ml浓度未出现毒性体征。在持续输注布比卡因120小时期间，Cpmax为4.9（0.7）μg/ml，tCpmax为48（5 - 96）小时。未出现毒性症状或体征。对R-和S-布比卡因浓度的单独测量显示出浓度-时间曲线显著不同。
