青光眼患者和正常受试者的眼动脉血流速度
Ophthalmic artery flow velocity in glaucomatous and normal subjects.
作者信息
Rojanapongpun P, Drance S M, Morrison B J
机构信息
Department of Ophthalmology, University Hospital, University of British Columbia, Canada.
出版信息
Br J Ophthalmol. 1993 Jan;77(1):25-9. doi: 10.1136/bjo.77.1.25.
The velocity of blood flow in the ophthalmic artery was measured with a transcranial Doppler ultrasound (2 MHz). Sixty patients with chronic open angle glaucoma (COAG), 42 patients with normal tension glaucoma (NTG), and 35 normals were studied. Peak flow velocity (peak), mean-enveloped velocity (mean) and diastolic velocity were compared in the three groups. The COAG patients and the NTG patients showed a significant reduction of all three Doppler flow velocities compared with the normals (COAG vs normal, p = 0.013, 0.019, and 0.009; NTG vs normal, p = < 0.001, < 0.001, and < 0.001 for peak, mean and diastolic flow velocity respectively). The NTG patients also had a significant slower mean flow velocity than the COAG patients (p = 0.016), but not for peak and diastolic flow velocities (p = 0.060 and 0.052 respectively). Based on ophthalmic flow velocity values, many NTG patients and a few COAG patients had slower flow velocities than the normals. The significance of these haemodynamic differences is not yet known.
采用经颅多普勒超声（2兆赫）测量眼动脉中的血流速度。研究了60例慢性开角型青光眼（COAG）患者、42例正常眼压性青光眼（NTG）患者和35名正常人。比较了三组的峰值流速（peak）、平均包络流速（mean）和舒张期流速。与正常人相比，COAG患者和NTG患者的所有三种多普勒流速均显著降低（COAG与正常人相比，峰值、平均和舒张期流速的p值分别为0.013、0.019和0.009；NTG与正常人相比，峰值、平均和舒张期流速的p值分别<0.001、<0.001和<0.001）。NTG患者的平均流速也显著慢于COAG患者（p = 0.016），但峰值和舒张期流速无显著差异（分别为p = 0.060和0.052）。基于眼流速值，许多NTG患者和少数COAG患者的流速比正常人慢。这些血流动力学差异的意义尚不清楚。
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