制霉菌素可能不会在薄脂质膜中形成通道的证据。
Evidence that nystatin may not form channels in thin lipid membranes.
作者信息
Romine W O, Sherette G R, Brown G B, Bradley R J
出版信息
Biophys J. 1977 Mar;17(3):269-74. doi: 10.1016/S0006-3495(77)85655-5.
Abstract
The mechanism of nystatin-induced conductance increases in planar bilayer membranes formed from lecithin/cholesterol (1:1) has been examined by spectral analysis of kinetic fluctuations. Lorentzian components of the power spectrum, characteristic of channel activity, were not observed for nystatin-doped membranes. Instead, the noise associated with this system (approximately 10(-27)A2/Hz) was in better agreement with that expected of a carrier mechanism involved in the transport of single charges in uncorrelated fashion. The implications of this result with respect to previous models of nystatin-induced conductance increases are discussed.
摘要
通过对动力学涨落的光谱分析，研究了制霉菌素在由卵磷脂/胆固醇（1:1）形成的平面双层膜中诱导电导增加的机制。对于掺杂制霉菌素的膜，未观察到功率谱的洛伦兹分量（通道活动的特征）。相反，与该系统相关的噪声（约10^(-27) A²/Hz）与以不相关方式参与单电荷传输的载体机制预期的噪声更相符。讨论了该结果对先前制霉菌素诱导电导增加模型的影响。
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