The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma, and pleural tissue after intravenous administration.
作者信息
Dan M, Torossian K, Weissberg D, Kitzes R
机构信息
Infectious Diseases Unit, Edith Wolfson Hospital, Holon, Israel.
出版信息
Eur J Clin Pharmacol. 1993;44(1):101-2. doi: 10.1007/BF00315290.
PMID:8436147
Abstract
We have studied the concentrations of ciprofloxacin in serum, bronchial mucosa, lung parenchyma, and pleural tissue after a single intravenous dose of 200 mg in 20 patients subjected to lung surgery. The concentrations of ciprofloxacin in the tissues exceeded that in the serum by 3-fold to 7-fold: serum 0.6 micrograms.ml-1, bronchial mucosa 1.9 micrograms.g-1, lung parenchyma 3.4 micrograms.g-, and pleural tissue 1.7 micrograms.g-1. The achievable concentrations of ciprofloxacin in the tissues of the lower respiratory tract are above the MICs for most lung pathogens.
摘要
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1
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2
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Rev Infect Dis. 1981 Jan-Feb;3(1):67-73. doi: 10.1093/clinids/3.1.67.
3
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Infection. 1986 Nov-Dec;14(6):299-300. doi: 10.1007/BF01643967.
4
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