环丙沙星在人胸腔积液中的渗透情况。
Penetration of ciprofloxacin into human pleural fluid.
作者信息
Jacobs F, Marchal M, de Francquen P, Kains J P, Gangji D, Thys J P
机构信息
Infectious Disease Clinic, Erasmus University Hospital, Brussels, Belgium.
出版信息
Antimicrob Agents Chemother. 1990 May;34(5):934-6. doi: 10.1128/AAC.34.5.934.
The concentrations of ciprofloxacin (1.5 mg/kg of body weight) in serum and in uninfected pleural exudates were studied after one and three intravenous injections had been given at 8-h intervals. The drug was assayed in serum and in pleural fluid by high-performance liquid chromatography. The peak concentrations in pleural fluid 1.5 h after one and three injections were (mean +/- standard error of the mean) 0.52 +/- 0.09 and 0.77 +/- 0.15 mg/liter, respectively; the corresponding 8-h concentrations were 0.19 +/- 0.05 and 0.39 +/- 0.10 mg/liter. At 1 and 8 h, the ratios of mean concentrations in pleural fluid to mean concentrations in serum were 112 and 158%, respectively, after one injection and 77 and 122% after three injections. This study suggested that there is a satisfactory pleural penetration of ciprofloxacin after intravenous injection.
在以8小时间隔进行一次和三次静脉注射后，研究了血清和未感染胸腔渗出液中环丙沙星（1.5毫克/千克体重）的浓度。通过高效液相色谱法测定血清和胸腔积液中的药物。一次和三次注射后1.5小时胸腔积液中的峰值浓度分别为（平均值±平均标准误差）0.52±0.09和0.77±0.15毫克/升；相应的8小时浓度为0.19±0.05和0.39±0.10毫克/升。在1小时和8小时时，一次注射后胸腔积液中平均浓度与血清中平均浓度的比值分别为112%和158%，三次注射后为77%和122%。该研究表明，静脉注射后环丙沙星在胸腔有令人满意的穿透性。
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