Roos K, Holm S E, Grahn E, Lind L
ENT-Department, Lundby Hospital, Göteborg, Sweden.
Scand J Infect Dis. 1993;25(1):31-5.
Recurrences are a common finding after antibiotic treatment of acute group A streptococcal tonsillitis. This has been attributed to several factors, among others a disturbed normal throat flora and especially a lack of alpha-streptococci. It thus seems logical in patients with recurrent streptococcal tonsillitis, to restore the normal alpha-streptococcal flora by reimplantation of alpha-streptococci. This was performed in a double blinded, randomized, placebo-controlled study. 36 patients with recurrent streptococcal group A tonsillitis were treated with antibiotics followed by either placebo (19 patients) or a pool of 4 selected alpha-streptococcal strains (17 patients) with good interfering activity against clinical isolates of beta-streptococci. No patient recurred during the first 2 months of follow-up in the alpha-treated group, but 7 in those treated with antibiotics and placebo. After 3 months 1 in the patient group treated with antibiotics and alpha-streptococci and 11 in the placebo-treated group recurred. These results are statistically highly significant and show that recolonisation with alpha-streptococci seems to offer a new way to lower the rate of recurrence in streptococcal throat infections.
复发性感染是A组链球菌急性扁桃体炎抗生素治疗后的常见现象。这归因于多种因素，其中包括正常咽喉菌群紊乱，尤其是缺乏α-链球菌。因此，对于复发性链球菌性扁桃体炎患者，通过植入α-链球菌来恢复正常的α-链球菌菌群似乎是合理的。这是在一项双盲、随机、安慰剂对照研究中进行的。36例复发性A组链球菌性扁桃体炎患者接受抗生素治疗，随后分别给予安慰剂（19例患者）或一组4种选定的对β-链球菌临床分离株具有良好干扰活性的α-链球菌菌株（17例患者）。在接受α-链球菌治疗的组中，随访的前2个月内没有患者复发，但接受抗生素和安慰剂治疗的组中有7例复发。3个月后，接受抗生素和α-链球菌治疗的患者组中有1例复发，安慰剂治疗组中有11例复发。这些结果在统计学上具有高度显著性，表明α-链球菌再定植似乎为降低链球菌性咽喉感染的复发率提供了一种新方法。
