Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure.
作者信息
Brill G M, Chen R H, Rasmussen R R, Whittern D N, McAlpine J B
机构信息
Anti-infective Research, Abbott Laboratories, Abbott Park, IL 60064.
出版信息
J Antibiot (Tokyo). 1993 Jan;46(1):39-47. doi: 10.7164/antibiotics.46.39.
PMID:8436558
Abstract
The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.
摘要
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