卡比菌素，由局限青霉产生的新型抗真菌剂。I. 生产、产生菌的分类学及生物活性。
Calbistrins, novel antifungal agents produced by Penicillium restrictum. I. Production, taxonomy of the producing organism and biological activity.
作者信息
Jackson M, Karwowski J P, Humphrey P E, Kohl W L, Barlow G J, Tanaka S K
机构信息
Anti-infective Research Division, Abbott Laboratories, Abbott Park, Illinois 60064.
出版信息
J Antibiot (Tokyo). 1993 Jan;46(1):34-8. doi: 10.7164/antibiotics.46.34.
A novel antibiotic complex, named the calbistrins, has been discovered in the culture broth of a soil fungus. The producing organism, designated AB 1875C-28, was identified as a strain of Penicillium restrictum. Calbistrin A, the most potent of the 4-membered complex, has MICs of 0.78 micrograms/ml against Candida albicans. Only poor activity is observed against non-candida yeasts, filamentous fungi and bacteria.
在一种土壤真菌的培养液中发现了一种名为卡尔比菌素的新型抗生素复合物。产生该复合物的菌株命名为AB 1875C-28，被鉴定为局限青霉。卡尔比菌素A是该四元复合物中活性最强的，对白色念珠菌的最低抑菌浓度为0.78微克/毫升。对非念珠菌酵母、丝状真菌和细菌仅观察到较弱的活性。
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