Mitchell R A
Department of Behavioural Sciences, Faculty of Health Sciences, University of Sydney, Lidcombe, NSW, Australia.
J Epidemiol Community Health. 1993 Feb;47(1):42-5. doi: 10.1136/jech.47.1.42.
The aim was to determine, employing non-invasive procedures, the prevalence of age related macular degeneration in persons 50 years of age and over.
A clinical investigation and a retrospective examination of ophthalmological records were employed in this study.
The study was conducted over the period 1988 to 1990 in the Western Metropolitan Health Region of New South Wales, Australia.
A total sample of 3283 subjects stratified by local government area, age, and sex was obtained from the source population. It proved possible to confirm ophthalmological diagnoses in only 2522 of these subjects.
All data were collected using accepted ophthalmological procedures and all diagnoses were confirmed through the use of independently derived ophthalmological records. A total of 428 subjects (13.0%) had a confirmed symmetrical diagnosis of age related macular degeneration. A total prevalence for diseased eyes of 14.9% was obtained. Prevalence of diseased eyes rose from 10.4% in those 50 to 64 years of age to 31.0% in those 85 years of age and over.
There are several sources of error which can affect such a large sample study and are identified. Despite these, the prevalence rates obtained in this study provide normative rates for age related macular degeneration for persons 50 years of age and over.
旨在采用非侵入性程序确定50岁及以上人群年龄相关性黄斑变性的患病率。
本研究采用了临床调查和眼科记录的回顾性检查。
该研究于1988年至1990年期间在澳大利亚新南威尔士州西部大都市卫生区进行。
从源人群中获得了按地方政府区域、年龄和性别分层的3283名受试者的总样本。结果发现，在这些受试者中，只有2522人能够确诊眼科疾病。
所有数据均通过公认的眼科程序收集，所有诊断均通过独立得出的眼科记录得到证实。共有428名受试者（13.0%）被确诊为对称性年龄相关性黄斑变性。患眼的总患病率为14.9%。患眼患病率从50至64岁人群中的10.4%上升至85岁及以上人群中的31.0%。
确定了几个可能影响如此大规模样本研究的误差来源。尽管如此，本研究得出的患病率为50岁及以上人群年龄相关性黄斑变性提供了标准患病率。
