State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
Rehabilitation Administration Department, National Institute of Hospital Administration, Chinese National Health and Family Planning Commission, Beijing, China.
Br J Ophthalmol. 2018 May;102(5):625-630. doi: 10.1136/bjophthalmol-2017-310368. Epub 2017 Aug 28.
To describe the prevalence of age-related macular degeneration (AMD) among older adults in rural southern mainland China.
Eligible persons aged 50 years or over were identified by geographically defined cluster sampling from Yangxi County, Guangdong Province, China. Participants underwent a standardised interview and comprehensive eye examinations from August to November in 2014. Digital retinal photographs were graded for AMD lesions using the Clinical Classification of Age-Related Macular Degeneration developed by the Beckman Initiative for Macular Research Classification Committee. Age-standardised prevalence of AMD and AMD lesions was calculated using the 2010 world population data and compared with those of other populations.
Of 5825 subjects who participated (90.7% response rate), 4881 (83.8%) had fundus photographs gradable for AMD. Early, intermediate and late AMD were present in 2003 (41.0%), 879 (18.0%) and 42 (0.86%) participants. The age-standardised prevalence of early, intermediate and late AMD was 40.4% (95% CI 39.6% to 41.2%), 17.6% (95% CI 17.0% to 18.2%) and 0.79% (95% CI 0.65% to 0.95%), respectively. Total AMD was more prevalent in men than in women (62.8% vs 57.1%).
AMD is an important public health concern for rural southern China, and the prevalence of AMD was higher in men than in women.
描述中国南方农村老年人群中年龄相关性黄斑变性（AMD）的患病率。
通过在中国广东省阳西县的地理定义聚类抽样，确定符合条件的 50 岁及以上的老年人。2014 年 8 月至 11 月，参与者接受了标准化的访谈和全面的眼部检查。使用贝克曼黄斑研究分类委员会制定的年龄相关性黄斑变性临床分类，对数字视网膜照片进行 AMD 病变分级。使用 2010 年世界人口数据计算 AMD 和 AMD 病变的年龄标准化患病率，并与其他人群进行比较。
在 5825 名参与的受试者中（应答率为 90.7%），有 4881 名（83.8%）的眼底照片可用于 AMD 分级。早期、中期和晚期 AMD 分别存在于 2003 年的 2003 名（41.0%）、879 名（18.0%）和 42 名（0.86%）参与者中。早期、中期和晚期 AMD 的年龄标准化患病率分别为 40.4%（95%CI 39.6%至 41.2%）、17.6%（95%CI 17.0%至 18.2%）和 0.79%（95%CI 0.65%至 0.95%）。男性总 AMD 的患病率高于女性（62.8%比 57.1%）。
AMD 是中国南方农村地区一个重要的公共卫生问题，男性 AMD 的患病率高于女性。
