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由21号染色体编码的人类γ干扰素受体辅助因子转导诱导2',5'-寡腺苷酸合成酶、抗病毒细胞病变效应和主要组织相容性复合体I类抗原的信号。

The human gamma interferon receptor accessory factor encoded by chromosome 21 transduces the signal for the induction of 2',5'-oligoadenylate-synthetase, resistance to virus cytopathic effect, and major histocompatibility complex class I antigens.

作者信息

Kalina U, Ozmen L, Di Padova K, Gentz R, Garotta G

机构信息

Pharmaceutical Research New Technologies, Hoffmann-La Roche Ltd., Basel, Switzerland.

出版信息

J Virol. 1993 Mar;67(3):1702-6. doi: 10.1128/JVI.67.3.1702-1706.1993.

DOI:10.1128/JVI.67.3.1702-1706.1993
PMID:8437239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC237547/
Abstract

Mouse fibroblasts, and human-mouse hybrid fibroblasts carrying only human chromosome 21, were transfected with cDNA encoding full-length human gamma interferon (IFN-gamma) receptor or chimeric IFN-gamma receptor (extracellular domain of the human receptor; transmembrane and intracellular domains of mouse origin). These transfected mouse cells were sensitive to human IFN-gamma only when human chromosome 21 was present. These results show that the species-specific accessory protein encoded by human chromosome 21 interacts with the extracellular domain of human IFN-gamma receptor and transduces the IFN-gamma signal not only for up-regulation of mouse major histocompatibility complex class I antigen expression but also for the induction of 2',5'-oligoadenylate-synthetase and resistance to virus cytopathic effect.

摘要

用编码全长人γ干扰素（IFN-γ）受体或嵌合IFN-γ受体（人受体的胞外结构域；小鼠来源的跨膜和胞内结构域）的cDNA转染小鼠成纤维细胞以及仅携带人21号染色体的人-鼠杂种成纤维细胞。只有当存在人21号染色体时，这些转染的小鼠细胞才对人IFN-γ敏感。这些结果表明，人21号染色体编码的物种特异性辅助蛋白与人IFN-γ受体的胞外结构域相互作用，并转导IFN-γ信号，不仅用于上调小鼠主要组织相容性复合体I类抗原的表达，还用于诱导2',5'-寡腺苷酸合成酶以及产生对病毒细胞病变效应的抗性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc22/237547/58a2f65002a2/jvirol00024-0582-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc22/237547/58a2f65002a2/jvirol00024-0582-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc22/237547/58a2f65002a2/jvirol00024-0582-a.jpg

相似文献

1
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Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8737-41. doi: 10.1073/pnas.90.18.8737.

本文引用的文献

1
Specific molecular activities of recombinant and hybrid leukocyte interferons.重组和杂交白细胞干扰素的特定分子活性。
J Biol Chem. 1982 Oct 10;257(19):11497-502.
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A convenient and rapid cytopathic effect inhibition assay for interferon.一种简便快速的干扰素细胞病变效应抑制试验。
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Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.超氧化物歧化酶：改进的测定方法及一种适用于丙烯酰胺凝胶的测定方法。
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The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase-B traits to chromosome G-21.人类干扰素诱导的抗病毒蛋白基因与吲哚酚氧化酶-B性状与G-21染色体的连锁。
J Exp Med. 1973 Feb 1;137(2):317-30. doi: 10.1084/jem.137.2.317.
5
Human chromosomes 6 and 21 are required for sensitivity to human interferon gamma.对人γ干扰素敏感需要人类6号和21号染色体。
Proc Natl Acad Sci U S A. 1987 Jun;84(12):4151-5. doi: 10.1073/pnas.84.12.4151.
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The gene for the human immune interferon receptor is located on chromosome 6.
Proc Natl Acad Sci U S A. 1986 Jan;83(2):384-8. doi: 10.1073/pnas.83.2.384.
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Structure and membrane topology of the high-affinity receptor for human IFN-gamma: requirements for binding IFN-gamma. One single 90-kilodalton IFN-gamma receptor can lead to multiple cross-linked products and isolated proteins.
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8
Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.通过免疫印迹法在人类细胞中鉴定出四种不同形式的干扰素诱导的2',5'-寡腺苷酸合成酶。
J Biol Chem. 1987 Mar 15;262(8):3852-7.
9
The extracellular domain of the human interferon gamma receptor interacts with a species-specific signal transducer.人γ干扰素受体的胞外结构域与一种物种特异性信号转导子相互作用。
Mol Cell Biol. 1991 Dec;11(12):5860-6. doi: 10.1128/mcb.11.12.5860-5866.1991.
10
Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.
J Biol Chem. 1991 Oct 15;266(29):19626-35.