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1
Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen.预防老年髋部骨折患者静脉血栓栓塞：低剂量肝素、双嘧达莫、阿司匹林和氟比洛芬的研究
Br Med J. 1977 Feb 26;1(6060):535-7. doi: 10.1136/bmj.1.6060.535.
2
Dipyridamole-aspirin versus low doses of heparin in the prophylaxis of deep venous thrombosis in abdominal surgery.双嘧达莫 - 阿司匹林与小剂量肝素预防腹部手术深静脉血栓形成的比较
Thromb Res. 1979 Feb-Mar;14(2-3):399-403. doi: 10.1016/0049-3848(79)90248-2.
3
Are agents affecting platelet functions clinically useful?影响血小板功能的药物在临床上有用吗？
Am J Med. 1976 Dec;61(6):897-914. doi: 10.1016/0002-9343(76)90414-9.
4
Is the incidence of deep vein thrombosis following myocardial infarction decreasing?
Aust N Z J Med. 1980 Apr;10(2):167-71. doi: 10.1111/j.1445-5994.1980.tb03706.x.
5
[Critical evaluation of the usefulness of drugs inhibiting platelet function in the prevention of postoperative deep venous thrombosis and in ischemic cardiopathy].
Recenti Prog Med. 1980 Apr;68(4):361-81.
6
[Prevention of thromboembolism with antiaggregants (author's transl)].
Langenbecks Arch Chir. 1977 Nov;345:359-64. doi: 10.1007/BF01305503.
7
Aspirin prophylaxis of venous thromboembolic disease following fracture of the upper femur.
Can J Surg. 1979 Sep;22(5):468-72.
8
Prevention of deep venous thrombosis and thrombo-embolism by dipyridamole and acetylsalicylic acid after reconstructive arterial surgery.双嘧达莫和阿司匹林预防重建性动脉手术后的深静脉血栓形成和血栓栓塞
J Cardiovasc Surg (Torino). 1980 Jul-Aug;21(4):451-4.
9
Low dose heparin in the prevention of venous thromboembolism. Rationale and results.低剂量肝素预防静脉血栓栓塞症。理论依据与结果。
Thromb Diath Haemorrh. 1975 Feb 28;33(1):87-96.
10
[Prevention of postoperative thrombo-embolic complications. The principal methods, other than low-dose heparin].[术后血栓栓塞并发症的预防。除低剂量肝素外的主要方法]
Ann Chir. 1977 Nov;31(11):991-7.

引用本文的文献

1
Deep venous thrombosis following different isolated lower extremity fractures: what is known about prevalences, locations, risk factors and prophylaxis?不同类型孤立性下肢骨折后的深静脉血栓形成：关于发病率、部位、危险因素及预防措施有哪些了解？
Eur J Trauma Emerg Surg. 2013 Dec;39(6):591-8. doi: 10.1007/s00068-013-0266-6. Epub 2013 Feb 21.
2
Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.骨科手术患者静脉血栓栓塞症的预防：抗血栓治疗和血栓预防，第 9 版：美国胸科医师学会基于证据的临床实践指南。
Chest. 2012 Feb;141(2 Suppl):e278S-e325S. doi: 10.1378/chest.11-2404.
3
Heparin, low molecular weight heparin and physical methods for preventing deep vein thrombosis and pulmonary embolism following surgery for hip fractures.肝素、低分子量肝素及预防髋部骨折手术后深静脉血栓形成和肺栓塞的物理方法。
Cochrane Database Syst Rev. 2000;2002(2):CD000305. doi: 10.1002/14651858.CD000305.
4
Collaborative overview of randomised trials of antiplatelet therapy--III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Antiplatelet Trialists' Collaboration.抗血小板治疗随机试验协作概述——III：手术和内科患者中抗血小板预防对静脉血栓形成和肺栓塞的降低作用。抗血小板试验协作组
BMJ. 1994 Jan 22;308(6923):235-46.
5
Physiological changes due to age. Implications for the prevention and treatment of thrombosis in older patients.年龄导致的生理变化。对老年患者血栓形成的预防和治疗的影响。
Drugs Aging. 1994 Jul;5(1):20-33. doi: 10.2165/00002512-199405010-00003.
6
Deep vein thrombosis and anaesthetic technique in emergency hip surgery.急诊髋关节手术中的深静脉血栓形成与麻醉技术
Br Med J. 1980 Dec 6;281(6254):1528-9. doi: 10.1136/bmj.281.6254.1528.
7
[Thrombosis prevention with heparin/dihydroergotamine versus heparin/Sintrom in Ender nailing of pertrochanteric fractures].[肝素/双氢麦角胺与肝素/新抗凝剂在股骨转子间骨折髓内钉固定术中预防血栓形成的比较]
Unfallchirurgie. 1988 Feb;14(1):12-21.
8
Prophylaxis of venous thromboembolism.静脉血栓栓塞的预防
World J Surg. 1990 Sep-Oct;14(5):670-8. doi: 10.1007/BF01658824.
9
[Clinical and in-vitro studies of the therapeutical range of acetylsalicylic-acid to prevent deep vein thrombosis (author's transl)].
Klin Wochenschr. 1978 Nov 15;56(22):1113-8. doi: 10.1007/BF01477133.
10
Can we really prevent postoperative pulmonary emboli?我们真的能预防术后肺栓塞吗？
Br Med J. 1979 Jun 9;1(6177):1523-4. doi: 10.1136/bmj.1.6177.1523.

本文引用的文献

1
Prevention of venous thrombosis and pulmonary embolism in injured patients. A trial of anticoagulant prophylaxis with phenindione in middle-aged and elderly patients with fractured necks of femur.创伤患者静脉血栓形成和肺栓塞的预防。一项针对中老年股骨颈骨折患者使用苯茚二酮进行抗凝预防的试验。
Lancet. 1959 Dec 5;2(7110):981-9. doi: 10.1016/s0140-6736(59)91464-3.
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Effect of a pyrimidopyrimidine derivative on thrombus formation in the rabbit.一种嘧啶并嘧啶衍生物对家兔血栓形成的影响。
Nature. 1965 Oct 16;208(5007):255-7. doi: 10.1038/208255a0.
3
Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion.摄入乙酰水杨酸对二磷酸腺苷诱导的继发性聚集及其他血小板功能的抑制作用。
Proc Soc Exp Biol Med. 1968 Feb;127(2):547-51. doi: 10.3181/00379727-127-32737.
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Reduction in venous thromboembolism by agents affecting platelet function.
N Engl J Med. 1971 Jun 10;284(23):1287-92. doi: 10.1056/NEJM197106102842303.
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Studies of platelet and fibrinogen kinetics in patients with prosthetic heart valves.人工心脏瓣膜患者血小板和纤维蛋白原动力学的研究。
N Engl J Med. 1970 Dec 10;283(24):1302-5. doi: 10.1056/NEJM197012102832402.
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Theory and practice of minidose heparin in surgical patients. A status report.外科患者小剂量肝素的理论与实践。一份现状报告。
Circulation. 1973 Apr;47(4):671-6. doi: 10.1161/01.cir.47.4.671.
7
Small subcutaneous doses of heparin in prevention of venous thrombosis.小剂量皮下注射肝素预防静脉血栓形成。
N Engl J Med. 1973 Mar 15;288(11):545-51. doi: 10.1056/NEJM197303152881103.
8
Effect of dipyridamole on the incidence of clinically detectable deep-vein thrombosis.双嘧达莫对临床可检测到的深静脉血栓形成发生率的影响。
Lancet. 1969 Oct 4;2(7623):718-20. doi: 10.1016/s0140-6736(69)90429-2.
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Effects of salicylates on human platelets.
Lancet. 1968 Apr 13;1(7546):779-83. doi: 10.1016/s0140-6736(68)92228-9.
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Effect of dipyridamole on human platelet behaviour.双嘧达莫对人体血小板行为的影响。
Lancet. 1965 Sep 25;2(7413):603-6. doi: 10.1016/s0140-6736(65)90515-5.

预防老年髋部骨折患者静脉血栓栓塞：低剂量肝素、双嘧达莫、阿司匹林和氟比洛芬的研究

Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen.

作者信息

Morris G K, Mitchell J R

出版信息

Br Med J. 1977 Feb 26;1(6060):535-7. doi: 10.1136/bmj.1.6060.535.

DOI:10.1136/bmj.1.6060.535
PMID:843794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1605162/
Abstract

Low-dose heparin, dipyridamole (alone and in combination with aspirin), and flurbiprofen were evaluated as potential prophylactic agents against deep venous thrombosis in elderly patients with hip fractures. None of the agents that modify platelet behaviour could reduct the frequency of isotopically diagnosed venous thrombosis. Low-dose heparin reduced the overall frequency of venous thrombosis and its extent as judged by the frequency of bilaterally abnormal scans, but this reduction did not achieve statistical significance.

摘要

低剂量肝素、双嘧达莫（单独使用以及与阿司匹林联合使用）和氟比洛芬被评估为髋部骨折老年患者深静脉血栓形成的潜在预防药物。没有一种改变血小板行为的药物能够降低同位素诊断的静脉血栓形成的发生率。低剂量肝素降低了静脉血栓形成的总体发生率及其程度（通过双侧异常扫描的频率判断），但这种降低未达到统计学显著性。