Silpapojakul K, Chayakul P, Krisanapan S, Silpapojakul K
Department of Medicine, Songklanagarind Hospital, Prince of Songkla University, Thailand.
Q J Med. 1993 Jan;86(1):43-7.
One hundred and thirty-seven patients with murine typhus were reviewed. A history of direct contact with rats was rare, and none gave a history of flea bite. No seasonal trend was observed. Clinical presentations included fever (100%), hepatomegaly (24%), rash (20%) and non-specific signs. Complications were uncommon but included jaundice, pneumonia, renal insufficiency and meningitis. Only two patients died. A single 200 mg dose of doxycycline significantly shortened the duration of fever: 79% were afebrile in 48 h, compared to 15% of the untreated group.
对137例鼠型斑疹伤寒患者进行了回顾性研究。有直接接触老鼠史的情况很少见，且无人有跳蚤叮咬史。未观察到季节性趋势。临床表现包括发热（100%）、肝肿大（24%）、皮疹（20%）和非特异性体征。并发症不常见，但包括黄疸、肺炎、肾功能不全和脑膜炎。仅2例患者死亡。单次200mg剂量的强力霉素显著缩短了发热持续时间：48小时内79%的患者退热，而未治疗组为15%。
