肿瘤中的微核表达作为辐射敏感性的一项检测指标。
Micronuclei expression in tumors as a test for radiation sensitivity.
作者信息
Bakker P J, Tukker L J, Stap J, Veenhof C H, Aten J A
机构信息
Department of Medicine, Academic Medical Center, Amsterdam, The Netherlands.
出版信息
Radiother Oncol. 1993 Jan;26(1):69-72. doi: 10.1016/0167-8140(93)90028-7.
PMID:8438089
Abstract
Dose-effect curves were determined for the frequency of micronuclei and impairment of cell clonogenicity from two types of tumours of different sensitivity irradiated in situ. Micronucleated cells were measured 24, 48 and 72 h after treatment. The quantitative relationships between cell reproductive death and the induction of micronuclei are the same for both tumours.
摘要
测定了原位照射的两种不同敏感性肿瘤的微核频率和细胞克隆形成能力损伤的剂量效应曲线。在处理后24、48和72小时测量微核细胞。两种肿瘤细胞生殖死亡与微核诱导之间的定量关系相同。
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