产妇年龄与前置胎盘：一项基于人群的病例对照研究。
Maternal age and placenta previa: a population-based, case-control study.
作者信息
Zhang J, Savitz D A
机构信息
Carolina Population Center, University of North Carolina, Chapel Hill 27599-7400.
出版信息
Am J Obstet Gynecol. 1993 Feb;168(2):641-5. doi: 10.1016/0002-9378(93)90511-g.
OBJECTIVE
Our purpose was to determine if advanced maternal age has an adverse effect on placenta previa independent of other risk factors.
STUDY DESIGN
A population-based, case-control study was performed with North Carolina vital records from 1988 to 1990, individually matching controls to cases on maternal race, gravidity, parity, previous spontaneous or induced abortion, previous cesarean section, and gestational age at delivery.
RESULTS
A multivariate analysis showed that women aged 34 years or older had a two to three times higher risk of placenta previa in relation to women < 20 years old. A clear dose-response pattern was observed with increasing age.
CONCLUSION
Advancing maternal age appears to increase the risk of placenta previa independent of other factors.
目的
我们的目的是确定高龄产妇是否独立于其他危险因素而对前置胎盘产生不利影响。
研究设计
采用基于人群的病例对照研究，利用北卡罗来纳州1988年至1990年的生命记录，根据产妇种族、妊娠次数、产次、既往自然流产或人工流产史、既往剖宫产史和分娩时的孕周，将对照个体与病例进行匹配。
结果
多变量分析显示，34岁及以上的女性发生前置胎盘的风险是20岁以下女性的两到三倍。随着年龄的增长，观察到明显的剂量反应模式。
结论
产妇年龄增加似乎会独立于其他因素而增加前置胎盘的风险。
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