Sakai K, Ugawa Y, Genba K, Mannen T, Kanazawa I
Department of Neurology, School of Medicine, University of Tokyo, Japan.
Eur Neurol. 1993;33(1):83-9. doi: 10.1159/000116909.
In 6 patients with cortical myoclonus, the intervals between the positive peak of the premyoclonus cortical spike and the onset of the myoclonic jerk [interval (Sp-Mcl)] were precisely measured by the computer-assisted jerk-locked averaging method. The intervals (Sp-Mcl) were 13.0-15.8 ms for the abductor pollicis brevis, 8.0-10.4 ms for the extensor digitorum communis and 5.5 ms for the biceps brachii, respectively. These were apparently shorter than the normal latencies of the responses elicited by transcranial cortical stimulation. The difference between the interval (Sp-Mcl) and the spinal latency was -0.8 to 3.5 ms, which was not long enough for the time required for the descending volleys going down from the cortex to the spinal cord. We have concluded that the motor cortex is activated before the positive peak of the premyoclonus spike in cortical myoclonus.
在6例皮质肌阵挛患者中，采用计算机辅助的抽搐锁定平均法精确测量了肌阵挛前皮质棘波的正峰与肌阵挛性抽搐发作之间的间隔时间[间隔时间(Sp-Mcl)]。拇短展肌的间隔时间(Sp-Mcl)为13.0 - 15.8毫秒，指总伸肌为8.0 - 10.4毫秒，肱二头肌为5.5毫秒。这些时间明显短于经颅皮质刺激引发的正常反应潜伏期。间隔时间(Sp-Mcl)与脊髓潜伏期之间的差异为-0.8至3.5毫秒，这对于下行冲动从皮质传导至脊髓所需的时间来说不够长。我们得出结论，在皮质肌阵挛中，运动皮质在肌阵挛前棘波的正峰之前就被激活了。
