Kordower J H, Mufson E J
Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612.
J Comp Neurol. 1993 Jan 15;327(3):359-75. doi: 10.1002/cne.903270305.
The distribution of the p75 nerve growth factor receptor (NGFr) was determined within the developing human basal ganglia in specimens between weeks 16 through 40 of gestation, 5 years of age, and adulthood. Although NGFr-immunoreactive neurons were rarely seen in the caudate nucleus, a few such neurons were seen in the putamen between prenatal weeks 16 and 26 of development. At 26 and 40 weeks of gestation, the putamen also displayed NGFr-immunoreactive fibers of putative basal forebrain origin. Some of these fibers coursed through the putamen en route to the cortex while others appeared to remain within the putamen. The external segment of the globus pallidus contained dense collections of NGFr-immunoreactive neurons between 16 and 26 weeks of gestation, whereas the internal segment was devoid of immunoreactive perikarya. A few NGFr-immunoreactive neurons were observed within the globus pallidus at embryonic week 40. The expression of NGFr-immunoreactive neurons within the external segment of the globus pallidus was paralleled by a dense granular NGFr-immunoreactive terminal-like staining pattern within the subthalamic nucleus. This staining pattern was most intense at midgestation (weeks 21-26) and was not observed at 40 weeks of gestation or in adulthood. Interestingly, a similar NGFr-immunoreactive terminal-like pattern was also observed within the monkey subthalamic nucleus at embryonic day 120. These data indicate that NGF receptor mediated mechanisms may underlie developmental processes within the primate basal ganglia. The absence of NGFr-immunoreactive neurons within the caudate nucleus, and the paucity of such neurons in the putamen, suggests that NGF receptors play a limited role in primate neostriatal development. Alternatively, developmental events mediated through NGF receptors may occur prior to embryonic week 16. Furthermore, an NGFr/trophic interaction appears to underlie the development of the pallidal-subthalamic nucleus pathway.
在妊娠16至40周、5岁及成年期的标本中，确定了发育中的人类基底神经节内p75神经生长因子受体（NGFr）的分布。虽然在尾状核中很少见到NGFr免疫反应性神经元，但在发育的产前第16至26周期间，在壳核中可见少数此类神经元。在妊娠26周和40周时，壳核还显示出来自假定基底前脑的NGFr免疫反应性纤维。其中一些纤维穿过壳核通向皮质，而另一些似乎留在壳核内。苍白球外侧段在妊娠16至26周之间含有密集的NGFr免疫反应性神经元，而内侧段没有免疫反应性核周体。在胚胎第40周时，在苍白球内观察到少数NGFr免疫反应性神经元。苍白球外侧段内NGFr免疫反应性神经元的表达与丘脑底核内密集的颗粒状NGFr免疫反应性终末样染色模式平行。这种染色模式在妊娠中期（第21至26周）最为强烈，在妊娠40周或成年期未观察到。有趣的是，在胚胎第120天时，在猴丘脑底核内也观察到类似的NGFr免疫反应性终末样模式。这些数据表明，NGF受体介导的机制可能是灵长类基底神经节发育过程的基础。尾状核内缺乏NGFr免疫反应性神经元以及壳核中此类神经元的稀少，表明NGF受体在灵长类新纹状体发育中起有限作用。或者，通过NGF受体介导的发育事件可能发生在胚胎第16周之前。此外，NGFr/营养相互作用似乎是苍白球-丘脑底核通路发育的基础。
