Kido T, Nogawa K, Hochi Y, Hayano M, Honda R, Tsuritani I, Ishizaki M
Department of Hygiene, Chiba University School of Medicine, Japan.
J Appl Toxicol. 1993 Jan-Feb;13(1):43-7. doi: 10.1002/jat.2550130110.
Clearance methods were used to clarify the renal handling of calcium (Ca) and phosphorus (P) in a population with renal dysfunction induced by exposure to environmental cadmium (Cd). Seventy-six Cd-exposed subjects (32 men and 44 women) and 36 non-exposed subjects (18 men and 18 women) took part in this study. Fractional excretion of P was higher in the Cd-exposed subjects than in the non-exposed subjects, while that of Ca was equal to that of the non-exposed subjects. The urinary excretion rates of Ca and P tended to be lower in the Cd-exposed subjects than in the non-exposed subjects. The urinary excretion rate of Ca was closely related to creatinine clearance, while that of P was related to creatinine clearance and the percentage tubular reabsorption of phosphorus. It is thought that in Cd-induced renal dysfunction the urinary excretion of Ca depends on glomerular function, and no increased excretion of urinary Ca was observed by these clearance methods. It is also clarified that the parallelism in the urinary excretion of Ca and Na persists in Cd-exposed subjects with renal dysfunction.
采用清除率方法，研究环境镉（Cd）暴露所致肾功能不全人群中钙（Ca）和磷（P）的肾脏处理情况。76名镉暴露受试者（32名男性和44名女性）和36名未暴露受试者（18名男性和18名女性）参与了本研究。镉暴露受试者的磷排泄分数高于未暴露受试者，而钙排泄分数与未暴露受试者相当。镉暴露受试者的钙和磷尿排泄率往往低于未暴露受试者。钙的尿排泄率与肌酐清除率密切相关，而磷的尿排泄率与肌酐清除率及肾小管磷重吸收百分比有关。据认为，在镉诱导的肾功能不全中，钙的尿排泄取决于肾小球功能，通过这些清除率方法未观察到尿钙排泄增加。还明确了在镉暴露的肾功能不全受试者中，钙和钠的尿排泄仍保持平行关系。
