Halpern A C, Guerry D, Elder D E, Trock B, Synnestvedt M
Pigmented Lesion Study Group and Cancer Center, University of Pennyslvania, Philadelphia.
J Invest Dermatol. 1993 Mar;100(3):346S-349S. doi: 10.1111/1523-1747.ep12470256.
A historical cohort of 153 patients with dysplastic nevi was studied for the development of melanoma. Each subject had a minimum follow-up of 5 years, with an average study follow-up of 94 months. Eleven new melanomas developed in 11 patients between 11 and 143 months (average 61 months) into the study period. Age-adjusted melanoma incidence in the cohort was 692/100,000 person years. Development of melanoma was strongly correlated with prior personal and/or family history of melanoma. Even among the 89 patients with no personal or family history of melanoma, the age-adjusted incidence of melanoma was an alarming 154/100,000 person years. Within this small, non-randomly ascertained cohort no association could be discerned between melanoma incidence and total number of banal or dysplastic nevi. These findings support the public health significance of the recognition of dysplastic nevi and confirm the importance of family history in evaluating melanoma risk associated with dysplastic nevi.
对153例发育异常痣患者的历史队列进行了黑色素瘤发生情况的研究。每位受试者的随访时间至少为5年，研究的平均随访时间为94个月。在研究期间的11至143个月（平均61个月），11例患者出现了11例新发黑色素瘤。该队列中经年龄调整的黑色素瘤发病率为692/100,000人年。黑色素瘤的发生与既往个人和/或家族黑色素瘤病史密切相关。即使在89例无个人或家族黑色素瘤病史的患者中，经年龄调整的黑色素瘤发病率也高达令人担忧的154/100,000人年。在这个小的、非随机确定的队列中，未发现黑色素瘤发病率与普通痣或发育异常痣总数之间存在关联。这些发现支持了识别发育异常痣对公共卫生的重要性，并证实了家族史在评估与发育异常痣相关的黑色素瘤风险中的重要性。
