Shiokawa S, Yasuda M, Kikuchi M, Yoshikawa Y, Nobunaga M
Department of Clinical Immunology, Kyushu University, Oita, Japan.
J Rheumatol. 1993 Jan;20(1):147-50.
We have encountered 2 patients with mixed connective tissue disease (MCTD) associated with lymphadenopathy at the outset. Biopsy specimens of enlarged lymph nodes showed massive necrotizing lesions with follicular hyperplasia, which are occasionally observed in the involved lymph nodes of patients with systemic lupus erythematosus (SLE) and called lupus lymphadenitis. Usually, the only histologic finding of an involved lymph node in MCTD is lymphoid hyperplasia. These are the 2nd and 3rd cases of MCTD associated with lupus lymphadenitis. Our cases suggest that histologic studies of the swollen lymph nodes are not helpful in distinguishing MCTD from SLE.
我们遇到了2例起病时伴有淋巴结病的混合性结缔组织病（MCTD）患者。肿大淋巴结的活检标本显示有大量坏死性病变伴滤泡增生，这种情况偶尔会在系统性红斑狼疮（SLE）患者受累的淋巴结中观察到，称为狼疮性淋巴结炎。通常，MCTD患者受累淋巴结的唯一组织学表现是淋巴样增生。这是第2例和第3例与狼疮性淋巴结炎相关的MCTD病例。我们的病例表明，对肿大淋巴结进行组织学研究无助于区分MCTD和SLE。
