Skeggs L T, Kahn J R, Levine M, Dorer F E, Lentz K E
Circ Res. 1977 Feb;40(2):143-9. doi: 10.1161/01.res.40.2.143.
The blood pressure of rabbits with chronic one-kidney hypertension can be lowered to normal by immunization with hog kidney cortex preparations that do not contain renin, thus providing evidence for a new factor essential for the maintenance of an elevated blood pressure. A search for the new factor has led to the discovery of a hypertensive substance which we have named renopressin. Subcutaneous injection of the new substance into normal rabbits produces a delayed, slow increase in blood pressure, and after a few days the development of a moderate hypertension which persists indefinitely. The response of the blood pressure to renopressin is totally unlike that to renin. While the pressor action of renin can be blocked by an angiotensin II antagonist, the hypertension caused by renopressin cannot. Renin can increase the blood pressure of hypertensive rabbits; renopressin has no effect. The blood pressure of hypertensive rabbits and of normal rabbits made hypertensive by injection of renopressin can be lowered to normal by passive immunization with the same antibody preparation. The evidence is consistent with the possibility that renopressin and the agent causing the elevation of blood pressure in hypertensive rabbits are similar or identical.
用不含肾素的猪肾皮质制剂对患有慢性单肾高血压的兔子进行免疫，可使其血压降至正常，从而为维持血压升高的一种新因素提供了证据。对这种新因素的探寻导致发现了一种高血压物质，我们将其命名为肾加压素。给正常兔子皮下注射这种新物质会使血压出现延迟、缓慢的升高，几天后会发展为中度高血压并持续存在。血压对肾加压素的反应与对肾素的反应完全不同。虽然肾素的升压作用可被血管紧张素II拮抗剂阻断，但肾加压素引起的高血压却不能。肾素可使高血压兔子的血压升高；肾加压素则无此作用。通过用相同的抗体制剂进行被动免疫，可使高血压兔子以及因注射肾加压素而患高血压的正常兔子的血压降至正常。这些证据支持了肾加压素与导致高血压兔子血压升高的物质相似或相同的可能性。
