Skeggs L T, Kahn J R, Levine M, Dorer F E, Lentz K E
Circ Res. 1976 Sep;39(3):400-6. doi: 10.1161/01.res.39.3.400.
The arterial pressure of rabbits with chronic one-kidney hypertension can be lowered to normotensive levels by direct immunization with preparations made from the cortex of hog kidneys. Hypertensive rabbits that are immunized with large amounts of renin may develop high plasma antirenin titers without affecting their blood pressure. Removal of renin by chromatography on columns of immobilized antirenin yields preparations with little or no renin. Such preparations may be effective in lowering blood pressure although they do not elicit the formation of plasma antirenin and the rabbits remain sensitive to challenging doses of rabbit renin. The evidence suggests that an unknown substance is responsible for the development of a cross-reacting antibody that neutralizes an unknown factor that is essential for the maintence of an elevated blood pressure level in rabbits with chronic one-kidney hypertension.
用猪肾皮质制成的制剂直接免疫，可使患有慢性单肾高血压的家兔动脉血压降至正常血压水平。用大量肾素免疫的高血压家兔，可能会产生高血浆抗肾素滴度，但不影响其血压。通过固定化抗肾素柱色谱法去除肾素，可得到肾素含量很少或没有肾素的制剂。这类制剂可能有效降低血压，尽管它们不会引发血浆抗肾素的形成，而且家兔对挑战性剂量的兔肾素仍保持敏感。证据表明，一种未知物质导致了交叉反应抗体的产生，该抗体中和了一种未知因子，而这种未知因子对于维持慢性单肾高血压家兔的血压升高至关重要。
