单肾单夹高血压的一种新机制。

A new mechanism in one-kidney, one clip hypertension.

作者信息

Skeggs L T, Dorer F E, Lentz K E, Kahn J R, Emancipator S N

出版信息

Hypertension. 1985 Jan-Feb;7(1):72-80. doi: 10.1161/01.hyp.7.1.72.

DOI:10.1161/01.hyp.7.1.72

Abstract

The renin-angiotensin system does not appear to be involved in the maintenance of elevated blood pressure in experimental one-kidney, one clip hypertension. Paradoxically, direct immunization with purified hog kidney renin lowers the blood pressure of rabbits with this form of hypertension. Antirenin antibodies were removed and the IgG fraction prepared from the plasma of such immunized rabbits. The antibodies thus obtained lowered the blood pressure of other hypertensive rabbits. The same antibodies, detected with a fluorescein-labeled second antibody, stained the cytoplasm of smooth muscle and certain other cells in sections of kidney, aorta, carotid artery, heart, liver, pancreas, adrenal gland, and small intestine from normal and hypertensive rabbits. We suggest that renin is converted into a form that is present most conspicuously in arterial and arteriolar smooth muscle. Its function in this location is unknown but must involve vasoconstriction as its neutralization by specific antibody lowers the blood pressure of one-kidney, one clip hypertensive rabbits.

摘要

肾素 - 血管紧张素系统似乎并未参与实验性单肾、单夹型高血压中血压升高的维持过程。矛盾的是，用纯化的猪肾素进行直接免疫可降低患这种高血压的兔子的血压。去除抗肾素抗体，并从这类免疫兔子的血浆中制备IgG组分。由此获得的抗体可降低其他高血压兔子的血压。用荧光素标记的二抗检测到的相同抗体，可使正常和高血压兔子的肾、主动脉、颈动脉、心脏、肝脏、胰腺、肾上腺和小肠切片中的平滑肌细胞质及某些其他细胞染色。我们认为肾素会转化为一种在动脉和小动脉平滑肌中最为显著存在的形式。其在该位置的功能尚不清楚，但由于其被特异性抗体中和会降低单肾、单夹型高血压兔子的血压，所以其功能必定涉及血管收缩。