Siegel N J, Feldman R A, Lytton B, Hayslett J P, Kashgarian M
Circ Res. 1977 Apr;40(4):379-84. doi: 10.1161/01.res.40.4.379.
To examine the role of intrarenal hemodynamics in in obstructive nephropathy, we determined cortical blood flow distribution (CBFD) in rats with bilateral ureteral occlusion (BUO) and unilateral ureteral occlusion (UUO) during and after release of obstruction. Prior to release of obstruction of 24 hours' duration, we found that outer cortical perfusion decreased by 20+/-5% in both BUO and UUO rats. Furthermore, one hour after release of BUO, there was rapid normalization of CBFD associated with a modest return of glomerular filtration rate (GFR), an almost complete return of renal blood flow (RBF), and a marked postobstructive diuresis. In contrast, after release of UUO, we observed that outer cortical perfusion remained decreased by 21+/-31%, both GFR and RBF remained markedly depressed, and no diuresis occurred. These data demonstrate (1) marked ischemia of the outer cortex in both BUO and UUO during obstruction, (2) a rapid return of CBFD to a normal pattern after release of BUO, but (3) persistent outer cortical ischemia following release of UUO.
为研究肾内血流动力学在梗阻性肾病中的作用，我们测定了双侧输尿管梗阻（BUO）和单侧输尿管梗阻（UUO）大鼠在梗阻解除期间及之后的皮质血流分布（CBFD）。在持续24小时的梗阻解除前，我们发现BUO和UUO大鼠的皮质外层灌注均下降了20±5%。此外，BUO解除后1小时，CBFD迅速恢复正常，同时肾小球滤过率（GFR）适度回升，肾血流量（RBF）几乎完全恢复，且出现明显的梗阻后利尿。相比之下，UUO解除后，我们观察到皮质外层灌注仍下降21±31%，GFR和RBF仍显著降低，且未出现利尿。这些数据表明：（1）梗阻期间BUO和UUO的皮质外层均存在明显缺血；（2）BUO解除后CBFD迅速恢复至正常模式；（3）UUO解除后皮质外层持续缺血。
