Söderholm J, Olaison G, Sjödahl R, Tagesson C
Dept of Medico-Surgical Gastroenterology, University Hospital, Linköping, Sweden.
Scand J Gastroenterol. 1993 Feb;28(2):163-7. doi: 10.3109/00365529309096064.
Intestinal absorption of orally administered polyethylene glycols with molecular weights of 634-1250 was investigated in 55 patients with Crohn's disease and in 20 healthy controls and was related to smoking habits at the time of testing. In the Crohn patients the polyethylene glycol absorption was also related to smoking habits at the time of diagnosis. Absorption of polyethylene glycols was impaired in Crohn patients compared with controls, but within both groups no difference was found among smokers, ex-smokers, and never-smokers (p > 0.05). Among the Crohn patients, those who smoked at the time of diagnosis had less impaired absorption (p < 0.02) of the smaller polyethylene glycols (634-942 Da) than those who did not. These data do not support the concept of altered intestinal permeability as the mechanism by which smoking influences Crohn's disease.
对55例克罗恩病患者和20名健康对照者口服分子量为634 - 1250的聚乙二醇后的肠道吸收情况进行了研究，并与测试时的吸烟习惯相关。在克罗恩病患者中，聚乙二醇的吸收也与诊断时的吸烟习惯相关。与对照组相比，克罗恩病患者中聚乙二醇的吸收受损，但在两组中，吸烟者、戒烟者和从不吸烟者之间未发现差异（p>0.05）。在克罗恩病患者中，诊断时吸烟的患者对较小聚乙二醇（634 - 942 Da）的吸收受损程度低于不吸烟的患者（p<0.02）。这些数据不支持吸烟影响克罗恩病的机制是肠道通透性改变这一概念。
