Lindberg E, Söderholm J D, Olaison G, Tysk C, Järnerot G
Dept. of Pediatrics, Orebro Medical Center Hospital, Sweden.
Scand J Gastroenterol. 1995 Aug;30(8):780-3. doi: 10.3109/00365529509096327.
A deranged mucosal permeability, demonstrated in several studies, has been proposed to play a role in the pathogenesis of Crohn's disease. The possibility of a genetically determined alteration of paracellular transport has been indicated in some investigations. The identification of a group of monozygotic twin pairs concordant and discordant for Crohn's disease, prompted this investigation.
Intestinal absorption after an oral load of different-sized polyethylene glycols (mol.wt, 458-810) was studied as 6-h urinary recovery. The study groups comprised twins with Crohn's disease (n = 19) and their healthy twin siblings (n = 9), non-twin patients with Crohn's disease (n = 14), and healthy controls (n = 30).
No differences were found in the absorption of polyethylene glycols between the study groups.
The results give no support to the hypothesis of a genetically determined intestinal leakiness in Crohn's disease.
多项研究表明，黏膜通透性紊乱在克罗恩病的发病机制中起作用。一些研究指出存在由基因决定的细胞旁转运改变的可能性。一组克罗恩病同卵双胞胎的一致性和不一致性促使了这项研究。
口服不同大小的聚乙二醇（分子量458 - 810）后，通过6小时尿液回收率研究肠道吸收情况。研究组包括患有克罗恩病的双胞胎（n = 19）及其健康的双胞胎兄弟姐妹（n = 9）、非双胞胎克罗恩病患者（n = 14）和健康对照者（n = 30）。
研究组之间聚乙二醇的吸收没有差异。
结果不支持克罗恩病中存在由基因决定的肠道渗漏这一假说。
