Yeo P P, Lewis M, Evered D C
Clin Endocrinol (Oxf). 1977 Feb;6(2):159-65. doi: 10.1111/j.1365-2265.1977.tb02007.x.
Direct radioimmunoassay of free triiodothyronine (fT3) and free thyroxine (fT4) in serum dialysate has been performed in fifty-two normals, twenty-one hyperthyroid, and twenty-one hypothyroid patients. In health, there is an almost equimolar concentration of fT3 and fT4. In hyperthyroidism, the free thyroid hormone concentrations were clearly discriminated from the normals. In a proportion of the symptomatic hypothyroids studied, the free hormone values fell within the normal range, challenging the concept that free thyroid hormone concentrations are the sole determinants of thyroid status. In the population studied, there were statistically significant correlations between fT3 and fT4, as well as the free hormones with their respective total hormone levels. It is concluded that fT3 and fT4 estimated are unlikely to play a major role in the routine investigation of thyroid disease.
已对52名正常人、21名甲状腺功能亢进患者和21名甲状腺功能减退患者的血清透析液中的游离三碘甲状腺原氨酸（fT3）和游离甲状腺素（fT4）进行了直接放射免疫测定。在健康状态下，fT3和fT4的浓度几乎等摩尔。在甲状腺功能亢进症中，游离甲状腺激素浓度与正常人有明显区别。在部分有症状的甲状腺功能减退症患者中，游离激素值落在正常范围内，这对游离甲状腺激素浓度是甲状腺状态唯一决定因素的概念提出了挑战。在所研究的人群中，fT3和fT4之间以及游离激素与其各自的总激素水平之间存在统计学上的显著相关性。得出的结论是，所测定的fT3和fT4在甲状腺疾病的常规检查中不太可能起主要作用。
