Bernstein J M, Faden H F, Dryja D M, Wactawski-Wende J
Department of Otolaryngology, State University of New York, Buffalo.
Acta Otolaryngol. 1993 Jan;113(1):88-92. doi: 10.3109/00016489309135772.
The quantitative bacteriology of the adenoid was studied in otitis-prone and non-otitis-prone children. alpha-hemolytic Streptococci (Viridans Streptococci) appeared to be predominant normal flora in the healthy nasopharynx. There was a decrease in alpha-hemolytic Streptococci in the otitis-prone child compared to the non-otitis-prone child. Concomitantly, there appears to be an increase in both nontypable Haemophilus influenzae (NTHI) and S. pneumoniae in the nasopharyngeal flora in the otitis-prone child. The mechanisms responsible for this alteration of the micro-ecology of bacteria of the nasopharynx may be related, in part, to factors that alter mucociliary function. These factors could be viral infection, allergy, local and systemic immunological deficiency and the indiscriminate use of antibiotics. An understanding of the relationship between the normal flora and the potential pathogens may be important in the understanding of both the pathogenesis of otitis media (OM) and possibly the treatment of this disease entity.
对易患中耳炎和不易患中耳炎的儿童的腺样体进行了定量细菌学研究。α溶血性链球菌（草绿色链球菌）似乎是健康鼻咽部的主要正常菌群。与不易患中耳炎的儿童相比，易患中耳炎的儿童中α溶血性链球菌数量减少。与此同时，易患中耳炎的儿童鼻咽部菌群中不可分型流感嗜血杆菌（NTHI）和肺炎链球菌的数量似乎都有所增加。鼻咽部细菌微生态改变的机制可能部分与改变黏液纤毛功能的因素有关。这些因素可能是病毒感染、过敏、局部和全身免疫缺陷以及抗生素的滥用。了解正常菌群与潜在病原体之间的关系对于理解中耳炎（OM）的发病机制以及可能对这种疾病的治疗可能很重要。
