Araneo B A, Shelby J, Li G Z, Ku W, Daynes R A
Division of Cell Biology and Immunology, University of Utah School of Medicine, Salt Lake City 84132.
Arch Surg. 1993 Mar;128(3):318-25. doi: 10.1001/archsurg.1993.01420150074014.
Burned individuals display a reduced ability to elicit cellular and humoral immune responses and a depression in the vitro production of certain T-cell lymphokines. Treatment of burned mice with 100 micrograms of dehydroepiandrosterone within 1 hour after injury resulted in preserving a completely normal capacity to produce T-cell-derived lymphokines and to generate cellular immune responses. In addition, dehydroepiandrosterone-treated thermally injured mice demonstrated an above-normal ability to resist an induced infection with the intracellular pathogen, Listeria monocytogenes. Dehydroepiandrosterone-treated animals also did not exhibit the sustained plasma levels of interleukin 6 that normally accompany thermal injury and infection. Because of its antiglucocorticoid effects and positive immunoregulatory influences, we believe dehydroepiandrosterone to be a beneficial form of therapy for thermally injured individuals.
烧伤患者表现出引发细胞免疫和体液免疫反应的能力降低，以及某些T细胞淋巴因子的体外产生受到抑制。在受伤后1小时内用100微克脱氢表雄酮治疗烧伤小鼠，可使其产生T细胞衍生淋巴因子和产生细胞免疫反应的能力完全保持正常。此外，经脱氢表雄酮治疗的热损伤小鼠表现出高于正常水平的抵抗细胞内病原体单核细胞增生李斯特菌诱导感染的能力。经脱氢表雄酮治疗的动物也未表现出热损伤和感染通常伴随的白细胞介素6血浆水平持续升高。由于其抗糖皮质激素作用和积极的免疫调节影响，我们认为脱氢表雄酮是热损伤个体的一种有益治疗形式。
