产前酒精暴露可减轻大鼠戊四氮诱发的惊厥。
Prenatal alcohol exposure attenuates pentylenetetrazol-induced convulsions in rats.
作者信息
Abel E L, Berman R F, Church M W
机构信息
Department of Obstetrics/Gynecology, Wayne State University, Detroit, MI.
出版信息
Alcohol. 1993 Mar-Apr;10(2):155-7. doi: 10.1016/0741-8329(93)90096-7.
PMID:8442893
Abstract
Female rats prenatally exposed to alcohol were tested at 35 days of age for susceptibility to pentylenetetrazol (PTZ)-induced convulsions. There was a significant dose-response effect of PTZ. Contrary to expectations, alcohol-exposed females were slightly but still significantly less convulsion-prone than pair-fed controls. These results suggest prenatal alcohol exposure reduces the susceptibility to convulsions in rats.
摘要
对产前暴露于酒精的雌性大鼠在35日龄时进行测试，以检测其对戊四氮（PTZ）诱导惊厥的易感性。PTZ存在显著的剂量反应效应。与预期相反，暴露于酒精的雌性大鼠惊厥倾向略低，但仍显著低于配对喂养的对照组。这些结果表明，产前酒精暴露会降低大鼠对惊厥的易感性。
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