Loew D
Curr Med Res Opin. 1977;4(7):455-61. doi: 10.1185/03007997709109333.
The sulphonamide-free diuretic Bay g 2821 was tested under standardized conditions 43 oedema-free volunteers. The threshold dose was 10 mg (0.14 mg/kg). The doseresponse curve was practically linear for doses up to 80 mg. The excretion of sodium and chloride was very high, and that of potassium, magnesium and calcium markedly lower. Itarenal haemodynamic investigations showed that the inulin clearance was unchanged, and the PAH clearance increased slightly. The tubular reabsorption of sodium and chloride was inhibited. Side-effects after a single oral dose did not occur.
在标准化条件下，对43名无水肿的志愿者测试了无磺胺类利尿剂Bay g 2821。阈剂量为10毫克（0.14毫克/千克）。剂量高达80毫克时，剂量-反应曲线实际上呈线性。钠和氯的排泄非常高，而钾、镁和钙的排泄明显较低。肾脏血流动力学研究表明，菊粉清除率未变，对氨基马尿酸清除率略有增加。钠和氯的肾小管重吸收受到抑制。单次口服给药后未出现副作用。
