新型利尿剂Bay g 2821的作用机制

The mechanism of action of Bay g 2821: a new diuretic.

作者信息

Mussche M, Lameire N

出版信息

Curr Med Res Opin. 1977;4(7):462-8. doi: 10.1185/03007997709109334.

Abstract

Acute water diuresis and hydropenic studies were carried out in 7 healthy volunteers to investigate the site of action of a new non-sulphonamide diuretic, Bay g 2821. The effects of the drug on the concentrating and diluting mechanism, and on the renal handling of sodium, potassium, calcium, phosphorus and uric acid were studied. The results suggest sites of actions of Bay g 2821 at the proximal tubule and the medullary portion of the ascending limb of the loop of Henle.

摘要

对7名健康志愿者进行了急性水利尿和失水性研究，以调查一种新型非磺胺类利尿剂Bay g 2821的作用部位。研究了该药物对浓缩和稀释机制以及对钠、钾、钙、磷和尿酸肾脏处理的影响。结果提示Bay g 2821的作用部位在近端小管和髓袢升支髓质段。