Kirschfink M, Castro F F, Rother U, Nakhosteen J A, Deppisch R, Schmitz-Schumann M
Institute of Immunology, University of Heidelberg, FRG.
Int Arch Allergy Immunol. 1993;100(2):151-5. doi: 10.1159/000236402.
61 patients suffering from intrinsic (idiotypic) or extrinsic (allergic) asthma were investigated for signs of complement activation and for C3 phenotype distribution. Activation of both the classical and alternative pathway of the complement system and generation of the membrane attack complex could be assessed by ELISAs for the activation-specific protein-protein complexes C1rsC1 inhibitor, C3b(Bb)P and SC5b-9, respectively. A possible deficiency of the complement regulatory proteins C1 inhibitor, factor H and factor I was excluded. In contrast to earlier studies, C3 allele frequencies did not differ from those found in the healthy population. Our results support the role of complement activation during bronchial asthma and, thereby, provide further evidence for the inflammatory nature of the disease.
对61例患有内源性（独特型）或外源性（过敏性）哮喘的患者进行了补体激活迹象及C3表型分布的研究。补体系统经典途径和替代途径的激活以及膜攻击复合物的生成可分别通过酶联免疫吸附测定法（ELISA）检测激活特异性蛋白质-蛋白质复合物C1rsC1抑制剂、C3b（Bb）P和SC5b-9来评估。排除了补体调节蛋白C1抑制剂、因子H和因子I可能存在的缺陷。与早期研究不同，C3等位基因频率与健康人群中的频率没有差异。我们的结果支持补体激活在支气管哮喘中的作用，从而为该疾病的炎症性质提供了进一步的证据。
