Zuccato E, Venturi M, Di Leo G, Colombo L, Bertolo C, Doldi S B, Mussini E
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Dig Dis Sci. 1993 Mar;38(3):514-9. doi: 10.1007/BF01316508.
Since the metabolic activity of the colonic flora plays a definite role in colon cancer and an increased incidence of this disease is reported after cholecystectomy, we studied the metabolic activity of the colonic flora in a group of postcholecystectomy patients and matched controls by measuring, as representative end products of the bacterial metabolism, their fecal bile acids (BA), fecal 3-methylindole (SK) and indole (IN), and respiratory methane and hydrogen. Patients had significantly higher SK and lower IN, and, among BA, higher lithocholic (LCA) and chenodeoxycholic acid concentrations and LCA/deoxycholic acid ratio in the stools than controls. Similar differences from controls were reported for colon cancer. Comparable bacterial metabolic activities are thus operative in the large bowel of postcholecystectomized and colon cancer patients. This supports the biological plausibility of the association of cholecystectomy and colon cancer.
由于结肠菌群的代谢活性在结肠癌中起一定作用，且胆囊切除术后该疾病的发病率有所增加，我们通过测量作为细菌代谢代表性终产物的粪便胆汁酸（BA）、粪便3 - 甲基吲哚（SK）和吲哚（IN）以及呼吸甲烷和氢气，研究了一组胆囊切除术后患者和匹配对照组中结肠菌群的代谢活性。患者的粪便中SK显著升高而IN降低，在胆汁酸中，石胆酸（LCA）和鹅去氧胆酸浓度以及LCA/脱氧胆酸比值均高于对照组。结肠癌患者与对照组也存在类似差异。因此，胆囊切除术后患者和结肠癌患者的大肠中存在类似的细菌代谢活性。这支持了胆囊切除术与结肠癌关联的生物学合理性。
