大肠息肉或癌症患者粪便中的粪臭素和吲哚以及呼出气体中的甲烷和氢气。
Fecal skatole and indole and breath methane and hydrogen in patients with large bowel polyps or cancer.
作者信息
Karlin D A, Mastromarino A J, Jones R D, Stroehlein J R, Lorentz O
出版信息
J Cancer Res Clin Oncol. 1985;109(2):135-41. doi: 10.1007/BF00391888.
The object of this study was to explore the use of fecal skatole and indole and breath methane and hydrogen as metabolic markers of the anaerobic colonic flora in patients with unresected large bowel cancer or polyps. Patients with descending or sigmoid colon cancer were more likely to be breath methane excretors than control subjects, patients with proximal colon cancer, and patients with rectal cancer. Control subjects excreting breath methane excreted less fecal skatole than breath methane excretors in the following groups: patients with adenomatous polyps, all patients with colorectal cancer, patients with proximal colon cancer, patients with descending and sigmoid colon cancer, and patients with rectal cancer. These data suggest that fecal skatole excretion equal to or greater than 100 micrograms/g feces might be useful to discriminate colorectal cancer patients from control subjects. Twenty-nine percent (8 of 28) of the cancer patients had both "high" skatole levels and breath methane excretion compared with only 2% (1 of 41) of the control subjects (P less than 0.01).
本研究的目的是探讨粪便中粪臭素和吲哚以及呼出气中甲烷和氢气作为未切除的大肠癌或息肉患者厌氧结肠菌群代谢标志物的用途。降结肠或乙状结肠癌患者比对照组、近端结肠癌患者和直肠癌患者更有可能是呼出气甲烷排泄者。在以下几组中，呼出甲烷的对照组受试者粪便中粪臭素的排泄量低于呼出甲烷的受试者：腺瘤性息肉患者、所有结直肠癌患者、近端结肠癌患者、降结肠和乙状结肠癌患者以及直肠癌患者。这些数据表明，粪便中粪臭素排泄量等于或大于100微克/克粪便可能有助于将结直肠癌患者与对照组受试者区分开来。29%（28例中的8例）的癌症患者同时具有“高”粪臭素水平和呼出气甲烷排泄，而对照组受试者中只有2%（41例中的1例）如此（P<0.01）。
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