Alebouyeh M, Vossough P
Department of Paediatric Haematology/Oncology Shohada Medical Centre, Tehran, Iran.
Eur J Pediatr. 1993 Jan;152(1):21-3. doi: 10.1007/BF02072511.
The epidemiological pattern of Hodgkin disease (HD) was studied in 139 Iranian children with an age range of 2.5-15 years (mean age 8.3) over a 17-year period (1972-1989). The main features observed were: a high male to female ratio of 3.2:1, a high frequency of HD in toddlers and young school children (73%), the prevalence of mixed cellularity subtype (74.5%) and rare occurrence of lymphocyte depletion subtype (2%) the high occurrence of constitutional symptoms (57%) and the high rate of stage III and IV patients (73.5%). Response to the treatment consisting mainly of chemotherapy and/or radiotherapy was favourable and overall and disease-free survival rates of 91.4% and 74.2% were achieved over a follow up period of 6 months-17 years. According to these findings the epidemiological pattern of Iranian children with HD is similar to that occurring in rural areas of developed countries.
在1972年至1989年的17年期间，对139名年龄在2.5至15岁（平均年龄8.3岁）的伊朗儿童的霍奇金病（HD）流行病学模式进行了研究。观察到的主要特征为：男女比例高达3.2:1，幼儿和小学低年级儿童HD发病率高（73%），混合细胞型亚型患病率高（74.5%），淋巴细胞消减型亚型罕见（2%），全身症状发生率高（57%），III期和IV期患者比例高（73.5%）。主要由化疗和/或放疗组成的治疗反应良好，在6个月至17年的随访期内，总生存率和无病生存率分别达到91.4%和74.2%。根据这些发现，伊朗HD儿童的流行病学模式与发达国家农村地区的相似。
