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参与大肠杆菌K-12中粗糙型脂多糖核心生成的rfaS基因，在鼠伤寒沙门氏菌LT2的rfa基因簇中不存在。

The rfaS gene, which is involved in production of a rough form of lipopolysaccharide core in Escherichia coli K-12, is not present in the rfa cluster of Salmonella typhimurium LT2.

作者信息

Klena J D, Pradel E, Schnaitman C A

机构信息

Department of Microbiology, Arizona State University, Tempe 85287-2701.

出版信息

J Bacteriol. 1993 Mar;175(5):1524-7. doi: 10.1128/jb.175.5.1524-1527.1993.

DOI:10.1128/jb.175.5.1524-1527.1993
PMID:8444813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC193241/
Abstract

Partial sequencing of the rfa cluster of Salmonella typhimurium LT2 indicated a region of 336 bp between rfaP and rfaB in the site occupied by the rfaS gene in Escherichia coli K-12. This region does not contain a functional rfaS gene, although DNA analysis suggests that the region may have contained an ancestral gene. This conclusion that S. typhimurium LT2 lacks rfaS is supported by its lipopolysaccharide (LPS) gel phenotype, since LT2 does not make the lipooligosaccharide band characteristic of LPS from smooth strains of E. coli K-12.

摘要

鼠伤寒沙门氏菌LT2的rfa基因簇的部分测序表明，在大肠杆菌K-12中rfaS基因占据的位点上，rfaP和rfaB之间有一个336 bp的区域。尽管DNA分析表明该区域可能含有一个祖先基因，但该区域并不包含功能性的rfaS基因。鼠伤寒沙门氏菌LT2缺乏rfaS这一结论得到了其脂多糖（LPS）凝胶表型的支持，因为LT2不会产生来自大肠杆菌K-12光滑菌株的LPS特有的脂寡糖条带。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5944/193241/0026c3a2b007/jbacter00047-0326-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5944/193241/0026c3a2b007/jbacter00047-0326-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5944/193241/0026c3a2b007/jbacter00047-0326-a.jpg

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