对几种食欲抑制药物引起的纹状体高香草酸增加的耐受性。
Tolerance to the increase of striatal homovanillic acid elicited by several anorectic drugs.
作者信息
Jori A, Dolfini E
出版信息
Eur J Pharmacol. 1977 Feb 21;41(4):443-5. doi: 10.1016/0014-2999(77)90265-5.
Several anorectic drugs affect dopamine metabolism in the rat striatum, increasing the concentration of homovanillic acid (HVA). However 1- and d-amphetamine and mazindol develop a tolerance to the HVA increase. On the contrary, the effect of fenfluramine and S 992 is not reduced by sub-chronic treatments. Moreover, a cross-tolerance to this biochemical effect develops between amphetamine and mazindol, but pretreatment with fenfluramine or with S 992 does not induce cross-tolerance to amphetamine.
几种食欲抑制药会影响大鼠纹状体中的多巴胺代谢，提高高香草酸（HVA）的浓度。然而，左旋苯丙胺、右旋苯丙胺和马吲哚会对HVA浓度的升高产生耐受性。相反，芬氟拉明和S 992的作用不会因亚慢性治疗而减弱。此外，苯丙胺和马吲哚之间会对这种生化效应产生交叉耐受性，但用芬氟拉明或S 992预处理不会诱导对苯丙胺的交叉耐受性。
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