Weiss M, Milman B, Rosen B, Zimlichman R
Department of Medicine F, E. Wolfson Medical Center, Holon, Israel.
J Clin Endocrinol Metab. 1993 Mar;76(3):680-2. doi: 10.1210/jcem.76.3.8445026.
Clinical observations have long suggested that skin perfusion (SP), among other factors, depends on thyroid status. However, quantitative data concerning this relationship are rather sparse. This study characterizes SP by means of laser Doppler flowmetry (LDF) in various thyroid dysfunctional states. The data reveal that mean capillary flow velocity, capillary pulse wave amplitude, and capillary flow oscillation amplitude, but not capillary flow oscillation frequency, are increased in hyperthyroid patients and decreased in hypothyroid patients. Regaining the euthyroid state is accompanied by normalization of LDF parameters only in hyperthyroid patients. It is concluded that LDF is useful in monitoring the thyroid effect on SP. However, it may not be used as a biological marker for the thyroid status of a given individual.
长期以来，临床观察表明，皮肤灌注（SP）与其他因素一样，取决于甲状腺状态。然而，关于这种关系的定量数据相当稀少。本研究通过激光多普勒血流仪（LDF）对各种甲状腺功能障碍状态下的SP进行了表征。数据显示，甲亢患者的平均毛细血管血流速度、毛细血管脉搏波振幅和毛细血管血流振荡振幅增加，而甲减患者则降低，只有甲亢患者恢复到甲状腺功能正常状态时，LDF参数才会恢复正常。结论是，LDF有助于监测甲状腺对SP的影响。然而，它可能不能用作给定个体甲状腺状态的生物标志物。
