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科罗拉多蜱传热病毒在人类造血祖细胞内的复制。

Replication of Colorado tick fever virus within human hematopoietic progenitor cells.

作者信息

Philipp C S, Callaway C, Chu M C, Huang G H, Monath T P, Trent D, Evatt B L

机构信息

Division of HIV/AIDS, Centers for Disease Control, Atlanta, Georgia 30333.

出版信息

J Virol. 1993 Apr;67(4):2389-95. doi: 10.1128/JVI.67.4.2389-2395.1993.

DOI:10.1128/JVI.67.4.2389-2395.1993
PMID:8445735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC240408/
Abstract

Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

摘要

感染科罗拉多蜱传热病毒的患者会出现显著的中性粒细胞减少，以及血小板减少和轻度贫血。在本研究中，人骨髓CD34+细胞和人造血祖细胞系KG-1a细胞在体外被科罗拉多蜱传热病毒感染。人祖细胞中病毒复制的时间进程和形态学表现与成红细胞和HEL细胞中的相似，提示了临床血液学表现的一种可能机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/36f01aa74bcf/jvirol00025-0663-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/5a142d5f09bf/jvirol00025-0658-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/6f1b80c514b5/jvirol00025-0659-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/51b041020317/jvirol00025-0660-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/dd600473a465/jvirol00025-0661-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/bc9937d7d351/jvirol00025-0662-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/36f01aa74bcf/jvirol00025-0663-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/5a142d5f09bf/jvirol00025-0658-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/6f1b80c514b5/jvirol00025-0659-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/51b041020317/jvirol00025-0660-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/dd600473a465/jvirol00025-0661-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/bc9937d7d351/jvirol00025-0662-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d4/240408/36f01aa74bcf/jvirol00025-0663-a.jpg

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本文引用的文献

1
Experimental infection of rhesus monkeys with Colorado tick fever virus.用科罗拉多蜱传热病毒对恒河猴进行实验性感染。
Am J Pathol. 1959 Sep-Oct;35(5):1043-54.
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Colorado tick fever as a hematologic problem.
Am J Clin Pathol. 1960 Aug;34:118-24. doi: 10.1093/ajcp/34.2.118.
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An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1).一种源自人急性髓性白血病细胞系（KG-1）的未分化变体。
Blood. 1980 Aug;56(2):265-73.
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North American encephalitic arboviruses.北美脑炎虫媒病毒
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Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.造血作用的抗原分析。III. 一种由针对KG-1a细胞产生的单克隆抗体所定义的造血祖细胞表面抗原。
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5
HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression.HEL细胞：一种具有自发和诱导性珠蛋白表达的新型人类红白血病细胞系。
Science. 1982 Jun 11;216(4551):1233-5. doi: 10.1126/science.6177045.
6
Electron microscopic observations of Colorado tick fever virus in BHK 21 and KB cells.对科罗拉多蜱传热病毒在BHK 21细胞和KB细胞中的电子显微镜观察。
J Gen Virol. 1968 Sep;3(2):279-80. doi: 10.1099/0022-1317-3-2-279.
7
Colorado tick fever virus: an electron microscopic study.科罗拉多蜱传热病毒：一项电子显微镜研究。
Virology. 1968 May;35(1):28-40. doi: 10.1016/0042-6822(68)90302-4.
8
Persistence of Colorado tick fever virus in red blood cells.科罗拉多蜱传热病毒在红细胞中的持续性。
Am J Trop Med Hyg. 1974 May;23(3):530-2. doi: 10.4269/ajtmh.1974.23.530.
9
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