Oshiro L S, Dondero D V, Emmons R W, Lennette E H
J Gen Virol. 1978 Apr;39(1):73-9. doi: 10.1099/0022-1317-39-1-73.
Electron microscopic examination of haemopoietic liver tissue from mice infected in utero or when newborn showed inclusions of Colorado tick fever virus within erythroblasts, reticulocytes and erythrocytes. Inclusions were also seen within erythroblastoid cells undergoing mitosis. Other evidence of virus replication within erythropoietic cells was the presence of intracytoplasmic and intranuclear fibres, which have been shown to be associated with Colorado tick fever virus replication. The findings reported here support the hypothesis that virus replication within infected erythropoietic cells occurs concurrently with differentiation of the infected cell, resulting in the presence of virions within erythrocytes.
对子宫内或新生时感染的小鼠造血肝脏组织进行电子显微镜检查发现，成红细胞、网织红细胞和红细胞内有科罗拉多蜱传热病毒包涵体。在进行有丝分裂的成红细胞样细胞内也可见到包涵体。红细胞生成细胞内病毒复制的其他证据是存在胞质内和核内纤维，已证明这些纤维与科罗拉多蜱传热病毒复制有关。此处报告的研究结果支持以下假设：受感染的红细胞生成细胞内的病毒复制与受感染细胞的分化同时发生，导致红细胞内存在病毒粒子。
