Kritchevsky D
Fed Proc. 1977 Apr;36(5):1692-5.
There is evidence that type of diet may affect the course of chemical carcinogenesis. In experiments with acetylaminofluorene, rats maintained on stock diet exhibit fewer tumors than do rats fed semi-purified diets. Rats fed stock diet augmented with high levels of sodium cyclamate (2.5-10%), amaranth (5%) or Tween (15%) showed normal weight gain, whereas addition of these toxicants to a fiber-free basal diet caused severely restricted weight gain and decreased survival. The latter effect can be overcome by addition of 10% pectin, alfalfa or cellulose to the basal diet. On the other hand, mice fed a fiber-free diet survived pneumococcal infection better than did mice fed modified stock diets. The mechanism(s) by which fiber affects carcinogenicity or toxicity are unelucidated. The effect of fiber and other aspects of diet on drug action is an area of research that should be developed.
有证据表明饮食类型可能会影响化学致癌的进程。在用乙酰氨基芴进行的实验中，食用常规饲料的大鼠比食用半纯化饲料的大鼠出现的肿瘤更少。食用添加了高水平甜蜜素（2.5 - 10%）、苋菜红（5%）或吐温（15%）的常规饲料的大鼠体重正常增加，而在无纤维基础饲料中添加这些毒物会导致体重严重受限且存活率降低。通过在基础饲料中添加10%的果胶、苜蓿或纤维素可以克服后一种影响。另一方面，喂食无纤维饲料的小鼠比喂食改良常规饲料的小鼠在肺炎球菌感染中存活得更好。纤维影响致癌性或毒性的机制尚不清楚。纤维和饮食的其他方面对药物作用的影响是一个值得深入研究的领域。
